Effect of hydroalcoholic extract of Nectaroscordum tripedale on testicular tissue changes in diabetic male rats

Background: Medicinal herbs are important in the treatment of diabetes. Studies have shown that diabetes causes reproductive changes in the male population. This study aimed to examine the effect of the hydroalcoholic extract of Nectaroscordum tripedale on testicular tissue changes in diabetic male rat. Materials and Methods: In this experimental study, 40 male rats were randomly divided into five groups (n=8, each group). The first and third groups (normal control and diabetic control) received distilled water. The second group (sham) received 50 mg/kg hydroalcoholic extract and the fourth and fifth groups (diabetic treatment 1 and 2) received 50 and 100 mg / kg of hydroalcoholic extract of Nectaroscordum tripedale, respectively. Streptozotocin was used to induce diabetes. At the end of the period, after the anesthesia of the rat, the testicular tissue was isolated and tissue sections were prepared for examination of the testicular tissue changes in the experimental groups. Data were analyzed by one-way ANOVA and Tukey's test using the SPSS software. Results: According to the results of this study, the number of spermatozoa tubes and the number of sperm in the diabetic control group showed a significant decrease compared to normal and control groups (P=0.03). Nectaroscordum tripedale extract increased the number of sperm, and sperm tubes and improved testicular tissues in diabetic rats. Conclusion: It seems that the extract of Nectaroscordum tripedale has effects on reducing testicular tissue degradation and increasing the amount of sperm in diabetic rats.